They synthesise thousands of powerful chemical substances for diverse purposes such as defence against fungi, insects, infections, and Herbivorous animals. There are many medicinal, herbal plants that have been in use for many years. Some of the more common medicinal herbs include:
– Laevis. It is a herbal medicinal plant with a broad spectrum of applications. It is used to treat depression, anxiety, epilepsy and other disorders. This herb also treats gastrointestinal disorders such as irritable bowel syndrome, diarrhea and constipation. Some of the common medicinal, herbal plants that contain levels include: La Floribunda, Lindera Tongkat Ali, Catarrhina antidysentrica, Equisetum Arvense, Mimulus vulgaris, Myrrh, Poria Cocos, Scutellaria lateriflora, Solanum nigrum, and Vapor rub. Some of the drug interactions associated with the mentioned medicinal herbal plants are listed below.
The Treatment Of Depression
– Antipsychotic drugs (anti-depressants) are commonly prescribed in the treatment of depression. Because leaves has antidepressant properties, it was often used as an alternative to the traditional anticonvulsant medications (antipsychotics). It was first combined with Laevis to produce a compound called amitriptyline.
– Cyproterone is a hormone and a pituitary gland stimulant commonly used for women with polycystic ovarian syndrome (PCOS) or those who are obese. It can cause serious side effects such as abnormal growth, hair loss, decreased sex drive, and irregular menstrual cycle in women. The interaction between Laevis and cyproterone is considered moderate and might not be of clinical significance.
– Tricyclic antidepressants (TCA) are widely used to treat obsessive-compulsive disorders such as schizophrenia. Tofranil is a TCA that was originally marketed as “The miracle pill”. Based on the plant’s chemical structure, tea made from the leaves of the medicine came to be known as tricyclic.
Numerous Natural Products
– Herbal drug discovery companies have succeeded in drug development by combining numerous natural products. Combinations involving herbs from different botanical sources have yielded some promising results. In the case of St. John’s wort, the serotonergic antidepressant properties have been combined with a compound that prevents serotonin reabsorption. Clinical trials on this combination have recently started.
– Herbal remedies have also contributed to the success of certain drugs. The combination of ingredients used in Ayurvedic formulations is particularly effective in treating certain illnesses and diseases. Ayurvedic combinations are effective in treating depression, migraine headaches, chronic pain, rheumatism, diarrhea, asthma, digestive disorders, and sexual dysfunction in men and women. Other herbal remedies are believed to improve appetite and decrease drug interactions with herbal drugs.
Health Conditions Or Medical Issues
One of the greatest benefits of herbal medicines is their non-addictive nature. In fact, patients usually achieve relief without experiencing any side effects at all. However, it is important for consumers to remember that they can aggravate or even worsen certain health conditions or medical issues such as allergies, abnormal heart rhythms, diabetes and other cardiovascular problems. Patients who are allergic to conventional medications should avoid using bioavailability forms of these herbal remedies. Bioavailability refers to how quickly a medication enters the bloodstream. This form of treatment must be pursued under the supervision of a professional doctor.
There are three broad classifications of bioavailability: soluble, partially soluble, and insoluble. Soluble fibrous agents do not release drug into the bloodstream, but rather enter the blood lymph circulation and pass through white blood cells. Soluble inhibitors are the most widely used in bioavailability studies and the most studied drug compounds. Cyproterone, losartan, and lofexidene glycoside are examples of soluble inhibitors.
Terms Of Concentration
In the first clinical trial evaluating the bioavailability of the herbal extract, a total of 8 volunteers were treated with ten distinct compounds. Each participant had to take the herbal extract separately and assess its effect on his or her blood chemistry parameters over a period of several weeks. Three of the ten potential components showed significant effects in terms of concentration, efficiency, and toxicity. The study concluded that the most potent compounds appeared in the table 3.
Table 3 shows the effects of the selected components in terms of their concentration in the plasma of treated subjects. Except for lovastatin, all compounds except for the sulfaphenazole showed a significant concentration-to-effect relationship in plasma. Lovastatin was the only compound with an insignificant concentration in plasma. The most efficient inhibitors of this enzyme had a concentration in plasma of less than 10%. All other herbs had concentrations ranging from zero to infinity.
As expected, the IC 50 values for each compound are listed in the legend of the graph. The concentrations of compounds are indicated as a function of time, with one hundred milligrams indicating the concentration in a biological sample. The slope of the curve is the arithmetic mean of the concentration of each compound over a period of five days. Linear regression was performed using logistic values to estimate IC 50 values of each compound. A positive curve fit was obtained when the intercept was placed at the midpoint of the range of concentration for the selected group. A significant model is fitted by an analysis of variance that shows that the intercept is primarily determined by the slope of the curve and the intercept value is unrelated to the concentrations of the selected substances.